Instrumental Technique: ICP-MS

Instrumental Technique: ICP-MS

Price range: 330,00 € through 570,00 €

We will introduce you to the minimum parameters to consider for the proper definition of an ICP-MS method and its control. The concept of Instrumental Calibration will be reviewed in its different approaches (curve fitting with multiple points, use of the response factor, with and without internal standard, with and without matrix) and the criteria for its evaluation.

We will clarify and work on the validation parameters (linearity, trueness, and precision) as well as the estimation of the uncertainty of the results.

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COURSE PROGRAM

1. Introduction to ICP-MS

    • Equipment components
    • General concepts of the technique
    • Interferences
    • General equipment controls

2. Instrumental Calibration

    • Regression concept
    • Requirements
    • Regression control
    • Types of regressions
    • Use of internal standard
    • Use of matrix

3. Reference Materials: Characteristics and Uses

4. Method Development

    • Definition of Scope
    • Evaluation of potential interferences
    • Selection of lines and signal composition
    • Use of internal standard
    • Use of removal systems
    • Selection of calibration and working range
    • Robustness
    • Initial tests

5. Validation

    • Concept of Validation
    • Validation parameters and requirements
    • Definition of the Validation System and experiments
    • Parameter determination
    • Trueness
    • Precision
    • Limit of Quantification
    • Linearity
    • Uncertainty estimation

6. Quality Control and Associated Operations

    • Calibration verification
    • Method quality control
    • Process blanks
    • Reference materials
    • Spiked samples
    • Interlaboratory comparisons

COURSE PROGRAM

1. Introduction and General Concepts

    • Basic Concepts
      • Definitions
      • Analytical Techniques
    • Comparison and Applications
    • Detection Limits
    • General Equipment Controls

2. Introduction and General Concepts

    • Technique Overview
    • ICP-MS Equipment
      • Sample Introduction System
      • Plasma Generation System
      • Interface
      • Mass Spectrometer
      • Data Acquisition and Processing System
      • Interference Attenuation System

3. Sample Preparation

    • ICP-MS vs. LA-ICP-MS Equipment
    • Sample Preparation
      • Acid Digestion

4. Instrument Setup and Maintenance

5. Calibration

    • General Concepts
    • Calibration Curve
    • Fitting Parameters
      • Linear Correlation Coefficient (r) and Determination (r²)
      • Residuals
      • Slope (m)
      • Y-intercept
      • Standard Deviation of the Value
    • Criteria for Linearity Evaluation
    • Criteria for Fit Evaluation
    • Use of Standards
Condiciones Generales: View file

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